Prevalence of Mild Cognitive Impairment and Dementia in Patients Admitted to Non-neurological Rehabilitation Wards
Eligible age
45+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Cognitive impairment is common among older adults hospitalized for non-neurological conditions but often goes unrecognized, particularly in rehabilitation settings where clinical attention is mainly focused on physical recovery. The COGinREHAB study is a multicenter, prospective, longitudinal interventional study conducted at three rehabilitation centers of the Fondazione Don Carlo Gnocchi in Italy (Florence and Milan). The study will enroll 384 patients aged 45 years or older who are hospitalized for at least 7-10 days in cardiac, pulmonary, or orthopedic intensive rehabilitation units, or in intermediate care units, for conditions unrelated to the nervous system. At admission, all participants undergo a clinical and cognitive screening visit. Patients whose screening results suggest possible cognitive impairment then undergo a more extensive neuropsychological evaluation. In those with confirmed cognitive impairment, additional blood tests are performed to measure biomarkers of neurodegeneration (GFAP, neurofilament light chain, and phosphorylated tau-217), together with APOE genotyping and a non-contrast brain CT scan. In a subset of these patients, resting-state EEG, auditory event-related potentials, actigraphy, and overnight polysomnography are also performed. Patients with confirmed cognitive impairment are invited to a follow-up visit 12 months later to assess whether their cognitive profiles and biological markers have changed. The main purpose of the study is to estimate how frequently cognitive impairment occurs among patients admitted to non-neurological rehabilitation units, including how often it was previously undiagnosed. The study will also describe the clinical, biological, and neurophysiological profile of these patients and examine how cognitive impairment evolves over one year.
Sponsor: Fondazione Don Carlo Gnocchi ETS
You may qualify if…
- ✓ Age ≥45 years
- ✓ Hospitalization for at least 7-10 days for a non-neurological condition, in cardiac, pulmonary, or orthopedic intensive rehabilitation units, or intermediate care units
- ✓ Adequate fluency in the Italian language
- ✓ Provision of written informed consent
You may not qualify if…
- ✕ Illiteracy
- ✕ Severe, uncorrected visual impairment and/or hearing loss
- ✕ Severe verbal communication deficit
- ✕ Inability to remain seated for the duration of the assessment
- ✕ Inability to use the dominant upper limb
- ✕ Altered state of consciousness or alertness (e.g., delirium)
- ✕ Severe scalp skin lesions or dermatitis precluding electrode application for neurophysiological recordings
- ✕ Previous or current history of severe psychiatric disorders (e.g., psychotic disorders, bipolar disorder, severe major depressive disorder with psychotic symptoms, current suicidal risk, or other psychiatric conditions judged by the investigator to interfere with study participation, procedural compliance, or interpretation of results)
Where it's recruiting
Milan
Source: ClinicalTrials.gov · NCT07731334 · last updated 2026-08-10