PCOS and Brain Health
Eligible age
18–45 yrs
Accepts
Women
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
The purpose of this study is to determine how polycystic ovary syndrome (PCOS) impacts overall brain health, such as cerebral blood flow (CBF), brain structure and connectivity, and cognitive performance. 45 reproductive aged (18-45 years) individuals with ovaries, with and without PCOS, will be enrolled to complete brain structure and CBF scans via magnetic resonance imaging (MRI) over 2 testing visits and can expect to be on study for approximately 5 hours over a 1 to 3 month period.
Sponsor: University of Wisconsin, Madison
You may qualify if…
- ✓ Rotterdam criteria demonstrating two out of the three criteria. These are:
- ✓ 1. Presence of clinical hyperandrogenism or biochemical hyperandrogenism
- ✓ 2. A history of irregular menstrual cycles
- ✓ 3. Presence of polycystic ovarian morphology on ultrasound
- ✓ Regular menstrual cycles (not meeting criteria for irregular cycles above)
- ✓ No diagnosis of PCOS
- ✓ Controls may have isolated hirsutism or polycystic ovaries on ultrasound as long as they do not meet Rotterdam criteria for PCOS
You may not qualify if…
- ✕ Current pregnancy
- ✕ Preexisting diagnosis of type 1 diabetes
- ✕ Severe obesity (body mass index (BMI) greater than 45kg/m2)
- ✕ Preexisting diagnosis of hypertension requiring antihypertensive medication or blood pressure of greater than 160/100 on two separate occasions during clinical care
- ✕ History of neurologic disease or stroke
- ✕ History of myocardial infarction or deep venous thrombosis
- ✕ Endometriosis confirmed by prior laparoscopy
- ✕ Autoimmune conditions including lupus, multiple sclerosis, and active malignancy
Where it's recruiting
Madison
Source: ClinicalTrials.gov · NCT07727512 · last updated 2026-07-28