Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal
Eligible age
18–85 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
The overall goal of this project is to establish a novel design and control paradigm for modular, partial-assist powered orthoses (exoskeletons) to enhance voluntary lower-limb motion and manage pain in broad patient populations. Building upon a previous study period that addressed weakness from advanced age or muscle fatigue, this current period extends the technology to novel powered unloader orthoses designed to manage knee osteoarthritis (OA) pain. The investigators hypothesize that by providing 15-30% of biological joint torque, these motorized devices can reduce muscular contributions to painful loads on the joint's surfaces during activities of daily living (ADLs). The project aims to develop a task-agnostic, neural network-based controller and establish the feasibility of reducing knee pain and muscle effort in individuals with multi-compartment knee osteoarthritis.
Sponsor: University of Michigan
You may qualify if…
- ✓ Aged between 18 to 65 years
- ✓ Weigh less than 300 lbs (due to challenges in bracing heavier participants)
- ✓ BMI \< 40 (due to challenges in bracing heavier participants)
- ✓ Aged between 30 to 85 years
- ✓ Medical diagnosis of patellofemoral and tibiofemoral osteoarthritis
- ✓ Patient reported pain ≥ 4 out of 10 during activities of daily life (to avoid floor effects)
- ✓ Weigh less than 300 lbs (due to challenges in bracing heavier participants)
- ✓ BMI \< 40 (due to challenges in bracing heavier participants)
You may not qualify if…
- ✕ Pregnant (self-report)
- ✕ Any significant neuromuscular or musculoskeletal disorder that would interfere with the study
- ✕ Unable to walk for 20 minutes
- ✕ History of any cardiovascular, vestibular, or visual diseases and/or impairments that may interfere with the study
- ✕ Cognitive deficits that would impair their ability to give informed consent or impair their ability to follow simple instructions during the experiments. Cognitive deficits will be determined by a Mini-Mental State Examination (MMSE) score of \<22.
- ✕ Adults with a known allergy to medical grade tape
- ✕ Pregnant (self-report)
- ✕ Any recent lower-extremity fracture (within 6 months)
Where it's recruiting
Ann Arbor
Source: ClinicalTrials.gov · NCT07673328 · last updated 2026-06-29