The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The purpose of this study is to examine the effects of resistance exercise, such as weightlifting, on retention of muscle mass and mental health in individuals taking GLP-1 RAs (an obesity medication). Resistance exercise is focused on increasing the strength of participants' muscles, such as how much participant can lift. •The duration of this study is 3 months. This includes: * Orientation session to explain study protocol, exercise program, and complete questionnaire about participants' medical history and lifestyle. * Two health assessments at baseline and at 3 months. These assessments include body composition, resting blood pressure, cardiovascular function, and muscular strength. Both the resistance exercise group and the control group will complete assessments at baseline and again at 3 months. After the 3-month period, individuals in the control group may choose to participate in the exercise training and complete the optional 6-month assessments. * Personalized resistance exercise sessions for 60 minutes per session, twice per week, for 3 months.
Sponsor: University of Pittsburgh
You may qualify if…
- ✓ Initiating GLP-1 RAs prescribed by physician or advanced practice practitioner and willing to withhold the start of the drug until baseline assessment completed
- ✓ Non-Smoker
- ✓ ≥18 years old
- ✓ Obese: Body Mass Index 30-45 kg/m² or BMI ≥27 + ≥1 weight related comorbidity; either hypertension or sleep apnea confirmed by participant self-report
- ✓ Inactive: not meeting the current US exercise guidelines over the past 6 months
- ✓ Capable of performing the required exercise training
You may not qualify if…
- ✕ A serious heart condition, such as unstable heart disease or heart failure, irregular heartbeats that are not well controlled, severe narrowing of the heart valves, or any recent inflammation of the heart or its lining
- ✕ Cancer requiring treatment in the past 5 years
- ✕ Hypothyroidism/hyperthyroidism
- ✕ Personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia Syndrome type 2 (MEN2)
- ✕ Gastroparesis
- ✕ Chronic/idiopathic acute pancreatitis
- ✕ Hepatic disease or cirrhosis
- ✕ Struggle with alcohol or other substance abuse (heavy drinking (≥4 drinks/day or ≥8 drinks/week for women; ≥5 drinks/day or ≥15 drinks/week for men), or who score ≥3 on the Drug Abuse Screening Test (DAST-10))
Where it's recruiting
Pittsburgh
Source: ClinicalTrials.gov · NCT07652333 · last updated 2026-06-24