RecruitingRespiratory Syncytial Virus Infections+Metapneumovirus
A Study of Investigational RSV/hMPV Combination and Investigational hMPV Vaccines in Younger and Older Adults
Eligible age
18–80 yrs
Accepts
All genders
Locations
2 states
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The aim of this study is to evaluate the safety, reactogenicity, and immune response of the different formulations of the investigational RSV/hMPV combination vaccine and investigational hMPV vaccine in younger and older adults.
Sponsor: GlaxoSmithKline
You may qualify if…
- ✓ Participants are eligible to be included in the study only if all of the following criteria apply:
- ✓ Written informed consent obtained from the participant prior to performance of any study-specific procedure.
- ✓ Participants who can and will comply with the requirements of the protocol (e.g., completion of the eDiary, return for follow-up visits, ability to access and utilize a phone or other electronic communications).
- ✓ Note: For OA participants, in case of physical incapacity that would preclude the self-completion of the eDiaries, either site staff can assist the participant (for activities performed during site visits) and/or the participant may assign a caregiver to assist him/her with this activity (for activities performed at home). However, at no time will the site staff or caregiver evaluate the participant's health status while answering eDiaries or make decisions on behalf of the participant.
- ✓ Body Mass Index (BMI) between 18 kg/m\^2 and 33 kg/m\^2, inclusive.
- ✓ Specific inclusion criteria for OA
- ✓ A male or female between and including, 60 to 80 YOA at the time of the study intervention administration.
- ✓ Healthy participants or medically stable patients as established by medical history, physical examination (and normal screening laboratory tests including Grade 1 laboratory abnormalities that are not-clinically significant in Phase 1 only).
You may not qualify if…
- ✕ Participants are excluded from participating in the study if any of the following criteria apply:
- ✕ History of any reaction or hypersensitivity likely to be exacerbated by any component of the study intervention(s).
- ✕ Any medical condition that in the judgment of the investigator would make IM injection unsafe.
- ✕ Any confirmed or suspected immunosuppressive or immunodeficient condition resulting from disease (e.g., current malignancy, HIV) or immunosuppressive/cytotoxic therapy (e.g., medication used during cancer chemotherapy, organ transplantation, or to treat autoimmune disorders), based on medical history and physical examination (no laboratory testing required).
- ✕ Acute or unstable chronic pulmonary, cardiovascular, hepatic, or renal functional abnormality, as determined by physical examination and medical history.
- ✕ Documented history of HIV, HBV, HCV infection.
- ✕ History of RSV and /or hMPV-associated illness, diagnosed serologically or microbiologically in the last 12 months.
- ✕ Recurrent history or uncontrolled neurological disorders or seizures, or history of demyelinating conditions (including GBS).
Where it's recruiting
Kansas
Lenexa
Washington
Seattle
Source: ClinicalTrials.gov · NCT07628049 · last updated 2026-07-08