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RecruitingMetabolically Healthy Obesity

Gut, Immune, and Vascular Health in Metabolically Healthy Obesity

Eligible age

18–55 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

Yes

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About this study

The investigators seek to better understand how a single high-fat meal impacts gut, immune, and vascular outcomes in individuals with "metabolically healthy obesity" (obesity and largely normal cardiometabolic profile) and "metabolically healthy normal-weight individuals." Second, the investigators seek to understand how a prebiotic fiber (inulin) impacts gut, immune, and vascular outcomes in individuals with "metabolically healthy obesity."

Sponsor: Ball State University

You may qualify if…

  • ✓ 18-55 years old.
  • ✓ BMI is 18.5-24.9 kg/m2 or \>30kg/m2 (part 1). BMI \> 30 kg/m2 (part 2)
  • ✓ Not pregnant or expecting to become pregnant (females only).
  • ✓ Not postmenopausal (females only).
  • ✓ Have 0-1 risk factors based on blood pressure, blood sugar, triglycerides, and HDL-cholesterol ("good cholesterol").
  • ✓ Have not been diagnosed with an advanced cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes).
  • ✓ Have not been diagnosed with a chronic inflammatory or gastrointestinal condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
  • ✓ Do not regularly take anti-inflammatory drugs (more than 2x week) or are able to temporarily suspend use of anti-inflammatory drugs three days prior to the study visit.

You may not qualify if…

  • ✕ Not 18-55 years old.
  • ✕ BMI is not 18.5-24.9 kg/m2 or \>30kg/m2 (part 1). BMI is not \> 30 kg/m2 (part 2)
  • ✕ Pregnant or expecting to become pregnant (females only).
  • ✕ Postmenopausal (females only).
  • ✕ Do not have 0-1 risk factors based on blood pressure, blood sugar, triglycerides, and HDL-cholesterol ("good cholesterol").
  • ✕ Have been diagnosed with an advanced cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes).
  • ✕ Have been diagnosed with a chronic inflammatory or gastrointestinal condition (e.g., rheumatoid arthritis, inflammatory bowel disease).
  • ✕ Regularly take anti-inflammatory drugs (more than 2x week) or are unable to temporarily suspend use of anti-inflammatory drugs three days prior to the study visit.

Where it's recruiting

Indiana

Muncie

Source: ClinicalTrials.gov · NCT07559227 · last updated 2026-04-30

Gut, Immune, and Vascular Health in Metabolically Healthy Obesity · TrialPath