Menopause Effects on Cortico-reticular Functioning
Eligible age
50–59 yrs
Accepts
Women
Locations
0 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
Post-menopausal women who request to begin hormone-replacement therapy (HRT) are directed to the research team. The participants are tested before beginning HRT, after two months of HRT, and five months of HRT. Tests include strength performance, central nervous system functioning, body composition, resting metabolic rate, and vascular screening. The participants are provided a 12-week training intervention (2 x strength, 2 x endurance per week) that can be voluntarily followed between tests at month 2 and 5. Compliance with the training program is recorded. A minimum of 15 participants are needed a priori, but the investigators aim to recruit and test 20 women.
Sponsor: University of Jyvaskyla
You may qualify if…
- ✓ at least 6 months since their last period but no more than being 5 years post-menopausal
- ✓ basal follicular-stimulating hormone concentration \> 30 IU/L (confirmed post-recruitment)
- ✓ willing to start combined hormonal treatment
- ✓ womb and ovaries intact with normal functioning throughout reproductive age
- ✓ willing to provide informed consent
- ✓ does not have any of the exclusion criteria for TMS measurements according to Rossi et al. (2021 Clin Neurophysiol. 132(1):269-306.) (i.e. arterial hypertension, heart attack/seizure history, migraine, pacemaker or cochlear implant or other implanted metal/electronic device)
You may not qualify if…
- ✕ classified as excessively obese via BMI assessment (i.e., \>35 kg/m2)
- ✕ intra-uterine device usage during transition to menopause
- ✕ cardiovascular or skeletomuscular disease preventing strenuous physical activity
- ✕ smoker
- ✕ diagnosed psychiatric illness
- ✕ epilepsy
- ✕ other diagnosed injuries/illness affecting the neuromuscular system
Source: ClinicalTrials.gov · NCT07500922 · last updated 2026-05-01