Exercise and Protein Efficiency in T2D
Eligible age
65+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
In this randomized controlled trial, 30 older adults (aged\> 65 years; 15 with T2D, 15 controls) will participate in a 12-week progressive exercise training program. They will undergo pre- and post-testing that includes body composition measures; oral glucose tolerance testing; cardiovascular fitness and muscle performance testing; dietary protein efficiency assessed using the indicator amino acid oxidation (IAAO) method; and a gut microbiota trial. The dietary protein efficiency trial will include repeated ingestion of crystallized amino acids (drink) containing stable isotopes, urine samples, and breath samples. The gut microbiome trial will consist of a single ingestion of a Mediterranean-based modeled meal enriched with 13C-phenylalanine (in the drink) and repeated blood draws. Participants will also be asked to give a fecal sample after the gut microbiome trial.
Sponsor: University of Illinois at Urbana-Champaign
You may qualify if…
- ✓ At least 65 years old
- ✓ Body mass index: 25-40 kg/m\^2
- ✓ Female: Waist to hip ratio \>0.8
- ✓ Male: Waist to hip ratio \>1.0
- ✓ Free from structured exercise during the prior 6 months (mo) weight stable for the prior 6 months
- ✓ T2D group:
- ✓ Diagnosed by a physician with elevated glycosylated hemoglobin (HbA1c) \>6.5%
- ✓ Control group:
You may not qualify if…
- ✕ Uncontrolled diabetes (evidence of HbA1c \> 10%, prescription of insulin)
- ✕ Diagnoses of diabetic neuropathy or failing diabetic neuropathy screening
- ✕ Statins
- ✕ Peripheral edema Consumption of ergogenic-levels of dietary supplements that may affect muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic/catabolic pro-hormones (e.g., DHEA) within 6 weeks prior to participation.
- ✕ Untreated hypothyroidism, epilepsy, medications that affect vasoactivity, possibility of pregnancy, and any neurological, cardiovascular, or musculoskeletal disease that precludes exercise testing.
Where it's recruiting
Urbana
Source: ClinicalTrials.gov · NCT07477067 · last updated 2026-04-29