RecruitingAbdominal Aortic Aneurysm
PET Imaging of MMP Activation in AAA: Clinical Component
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
A first-in-human evaluation of \[64Cu\]-RYM2 with PET/CT will be performed to: a) assess its safety, biodistribution, and radiation dosimetry in normal volunteers (WU) and; b) in AAA patients undergoing surgery (WU and Yale), evaluate radiotracer pharmacodynamics and correlate PET imaging characteristics (WU) with ex vivo tissue measurements (Yale).
Sponsor: Washington University School of Medicine
You may qualify if…
- ✓ No history of claustrophobia or other preventing condition that has previously or would interfere with completion of protocol-specified imaging sessions.
- ✓ Able to comprehend and willing to follow instructions for the study procedures as called for by the protocol.
- ✓ Capable of lying still and supine within the PET/CT scanner for \~1 hour and follow instructions for breathing protocol during the CT portion.
- ✓ No illicit drug use or other inhaled drug use (including pharmacologic agents, recreational agents, or illicit drugs) within the past year.
- ✓ No known history of cardiac, pulmonary, hepatic or renal disease or diabetes
- ✓ BMI ≤ 40
- ✓ Men or women 40-80 years of age
- ✓ Willing and able to provide informed consent
You may not qualify if…
- ✕ Inability to receive and sign informed consent;
- ✕ Pregnant (confirmed by urine pregnancy test) and/or breastfeeding
- ✕ Patient with chronic renal disease whose glomerular filtration rate (GFR) is less than 30 mL/min/1.73 m2
- ✕ Patients with an unstable clinical condition that in the opinion of the principal investigators or designee precludes participation in the study.
- ✕ Is deemed likely to be unable to perform all research procedures for any reason, (e.g., subjects unable to lie still or inability to tolerate up to 60 minutes in a supine position with arms up during the PET imaging procedures due to chronic back/shoulder pain or arthritis as assessed by physical examination and medical history).
- ✕ Currently using recreational drugs.
- ✕ Body weight of \>300 lbs. (weight limit of the PET table).
- ✕ Currently enrolled in another study using an investigational drug or underwent a study the last year involving investigational use of radiotracers or CT would confound results or with a radiation exposure when combined with this study would be deemed as excessive by the Sponsor-Investigator.
Where it's recruiting
Missouri
St Louis
Source: ClinicalTrials.gov · NCT07473102 · last updated 2026-03-18