RecruitingAsthma
A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma
Eligible age
12+ yrs
Accepts
All genders
Locations
4 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The aim of this study is to evaluate the efficacy of depemokimab administered as an adjunctive therapy, in participants with Type 2 asthma at risk of exacerbations compared to the guideline recommended standard of care (SoC).
Sponsor: GlaxoSmithKline
You may qualify if…
- ✓ Adults and adolescents \>=12 years of age, at the time of signing the informed consent/assent. For countries where local regulations or the regulatory status of study medication permit enrolment of adults only, participants recruited will be \>=18 years of age.
- ✓ Participants must have a documented physician diagnosis of asthma for \>=2 years that meets the National Heart, Lung, and Blood Institute, National Institute for Health and Care Excellence or Global Initiative for Asthma guidelines
- ✓ Have previously confirmed history of at least 2 exacerbations over the last 3 years prior to screening, with at least 1 of those exacerbations occurring in the previous year prior to Screening Visit 1.
- ✓ Exacerbation requiring treatment with systemic Corticosteroid (CS), for at least 3 days, despite the use of low to medium dose Inhaled corticosteroids (ICS)/ Long-acting beta2-adrenergic receptor agonist (LABA).
- ✓ A well-documented requirement for treatment with low to medium dose ICS/LABA (in the 12 months prior to screening visit. Treatment should be stable for 3 months prior to screening. If participants are taking Maintenance and Reliever Therapy/Single Maintenance and Reliever Therapy regularly, the total daily dose should be incorporated into the assessment of low or medium dose ICS.
- ✓ Study will limit enrolment to a maximum of 40 percent (%) of participants on low dose ICS/LABA.
- ✓ Sex and Contraceptive/Barrier Requirements Male or eligible female Participants:
- ✓ Male Participants: Contraception for male participants with female partners is not required.
You may not qualify if…
- ✕ Participants have had 3 or more exacerbations in the last year prior to Visit 1.
- ✕ Participants on maintenance OCS or high dose ICS/LABA for asthma.
- ✕ Participants with a duration of asthma greater than (\>)20 years.
- ✕ Presence of a known pre-existing, clinically important lung condition other than asthma. This includes (but is not limited to) current infection, bronchiectasis, pulmonary fibrosis, bronchopulmonary aspergillosis, or a history of lung cancer. Participants with current diagnoses of emphysema or chronic bronchitis (Chronic Obstructive Pulmonary Disease other than asthma) are excluded.
- ✕ Participants with other conditions that could lead to elevated EOS such as hypereosinophilic syndromes including (but not limited to) Eosinophilic Granulomatosis with Polyangiitis (formerly known as Churg-Strauss Syndrome) or eosinophilic esophagitis.
- ✕ Participants who developed an exacerbation within 4 weeks before screening.
- ✕ Participants with a known, pre-existing parasitic infestation within 6 months prior to screening unless treated and evidenced to have been resolved.
- ✕ A known immunodeficiency (e.g. human immunodeficiency virus), other than that explained by the use of CS taken as therapy for asthma.
Where it's recruiting
California
Newport Beach
Florida
Aventura · Kissimmee · Miami
Oklahoma
Oklahoma City
South Dakota
Rapid City
Source: ClinicalTrials.gov · NCT07456033 · last updated 2026-06-25