Neuromodulation to Improve Grasping Function After SCI
Eligible age
18–75 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
The goal of this study is to restore the activities of late descending signals with a noninvasive stimulation approach in combination with hand motor training to improve hand function in persons with cervical SCI. The main question it aims to answer is if the inputs to late descending signals above the level of injury and the output of residual late descending signals below the level of injury could be increased. Specifically, in the first part of the study, 30 participants will complete 2 randomized sessions to compare the effect of intermittent theta burst stimulation combined with paired corticospinal motoneuronal stimulation. In the second part of the study, 24 participants will complete either combined stimulation protocol or sham stimulation protocol with exercise training.
Sponsor: State University of New York at Buffalo
You may qualify if…
- ✓ For individuals with SCI:
- ✓ Ages 18-75 years
- ✓ Chronic SCI (≥1 year of injury)
- ✓ Cervical injury at C8 or above
- ✓ Individuals who have MEP responses in at least one FDI muscle
You may not qualify if…
- ✕ Uncontrolled medical problems including pulmonary or cardiovascular disease
- ✕ Premorbid, ongoing major depression or psychosis, altered cognitive status
- ✕ History of head injury or stroke
- ✕ Metal plate in skull
- ✕ History of seizures
- ✕ Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs
- ✕ Pregnant females
- ✕ Individuals who suffer from a spinal cord disease such as spinal stenosis, spinal bifida or herniated cervical
Where it's recruiting
Buffalo
Source: ClinicalTrials.gov · NCT07433959 · last updated 2026-04-23