Prognostic Value of SII and SIRI in Obesity-Related Metabolic Complications
Eligible age
18+ yrs
Accepts
All genders
Locations
0 states
Healthy volunteers
Yes
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About this study
This observational study aims to evaluate the diagnostic and prognostic value of the systemic immune-inflammatory index (SII) and the systemic inflammation response index (SIRI) in individuals with overweight or obesity. The study will assess their association with obesity status, metabolic complications, lifestyle patterns, dietary indices, and established inflammatory biomarkers. Participants will undergo anthropometric assessment, laboratory testing, dietary evaluation, and follow-up for response to different obesity treatment modalities over 3 years. The study intends to determine whether SII and SIRI can serve as clinically useful predictors of metabolic risk and treatment outcomes of obesity.
Sponsor: University of Rijeka
You may qualify if…
- ✓ Age ≥ 18 years
- ✓ BMI 25.0-29.9 kg/m² (overweight) or BMI ≥ 30 kg/m² (obesity)
- ✓ Ability to attend scheduled clinical visits
- ✓ Willingness to provide informed consent
You may not qualify if…
- ✕ Pregnancy or breastfeeding
- ✕ Use of immunosuppressive therapy
- ✕ Active infection
- ✕ Inflammatory disease
- ✕ Malignancy
- ✕ Acute illness affecting immune parameters
- ✕ Conditions interfering with study participation (as assessed by the investigator)
- ✕ Known hematologic disorders affecting leukocyte or platelet counts
Source: ClinicalTrials.gov · NCT07431593 · last updated 2026-05-07