Amygdala Insula Retraining in the Management of Perimenopause Symptoms
Eligible age
38–60 yrs
Accepts
Women
Locations
1 state
Healthy volunteers
No
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About this study
The goal of this study is to evaluate a neuroplasticity-based mind-body intervention, Amygdala and Insula Retraining (AIR), compared to a wait-list control in individuals experiencing perimenopausal symptoms. Our research questions include: Does AIR reduce overall perimenopausal symptom burden compared to a wait-list control? Does AIR improve sleep disturbance, vasomotor symptom interference, fatigue, mood, anxiety, and quality of life in perimenopausal individuals? Are symptom changes associated with improvements in autonomic regulation and sleep parameters, as reflected by exploratory wearable measures including heart rate variability?
Sponsor: Chronic Conditions Research Fund
You may qualify if…
- ✓ Experiencing perimenopausal symptoms
- ✓ Meets STRAW+10 criteria based on self-assessment (-2 to +1c)
- ✓ Able to read and understand English
- ✓ Access to internet
You may not qualify if…
- ✕ Pregnancy
- ✕ Presence of a severe psychiatric condition requiring immediate clinical intervention
- ✕ Uncontrolled thyroid disease or prolactinoma
- ✕ Active cancer treatment
- ✕ Inability to provide informed consent
- ✕ Any medical or psychiatric condition that, in the judgment of the investigator or study team, would interfere with safe participation or study completion
Where it's recruiting
Decorah
Source: ClinicalTrials.gov · NCT07427459 · last updated 2026-06-29