RecruitingAsthma
Ventilation and Perfusion in Asthmatics
Eligible age
18–75 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Assess regional changes to perfusion and ventilation from inhaled corticosteroid (ICS) and Fast-acting beta-antagonist (FABA) among adult asthmatics using radiographically derived estimates of regional ventilation (V-distribution), ventilation defect percentage (VDP), and ventilation heterogeneity (VH).
Sponsor: University of Miami
You may qualify if…
- ✓ Physician diagnosis of asthma
- ✓ Baseline Forced Expiratory Volume in 1 Second (FEV1) \< 80% of predicted, with reversibility (10%) on post-bronchodilator spirometry
- ✓ Adults, 18-75 years of age
- ✓ Long-term inhaled controller medication consisting of or including an Inhaled corticosteroids (ICS) at a steady dose for at least 3 months before enrollment
You may not qualify if…
- ✕ Current cigarette smoking or a past history of \>10 pack-year smoking
- ✕ Current nicotine vaping
- ✕ Pregnant and breast-feeding women
- ✕ Respiratory infection within 4 weeks of proposed study date
- ✕ Forced Expiratory Volume in 1 Second (FEV1) \< 50%
- ✕ Inhaled corticosteroids (ICS)/fast-acting beta agonist (FABA) intolerance
- ✕ Use of beta-blockers
- ✕ Use of systemic glucocorticosteroids or oral methyl-xanthines within 30 days of planned study visit.
Where it's recruiting
Florida
Miami
Source: ClinicalTrials.gov · NCT07426458 · last updated 2026-05-05