RecruitingChronic Low Back Pain
MBM and taVNS for Low Back Pain and Depressive Symptoms
Eligible age
50–85 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
This two-arm randomized controlled trial aims to test the preliminary effect of home-based mindfulness-based meditation and transcutaneous auricular vagus nerve stimulation on managing pain and depressive symptoms among community-dwelling older adults with chronic low back pain and depressive symptoms; and the effect of home-based mindfulness-based meditation and transcutaneous auricular vagus nerve stimulation on the host Brain-Gut Axis.
Sponsor: Florida State University
You may qualify if…
- ✓ 1. aged 50 to 85 years old
- ✓ 2. intact cognition (examined by the Mini-Mental State Exam, ≥ 24)
- ✓ 3. experiencing moderate low back pain daily or almost every day at least the previous three months (≥3 out of 10 on numeric rating scale \[NRS\])
- ✓ 4. experiencing elevated depressive symptoms with the patient health questionnaire (PHQ-9) total score ranging between 5 to 19
- ✓ 5. able to speak and read English
- ✓ 6. not intent to change medication regimens for pain throughout the trial.
You may not qualify if…
- ✕ 1. serious underlying illness (e.g., malignant neoplasms),
- ✕ 2. other psychosis,
- ✕ 3. elevated suicide risk as indicated by the Columbia-Suicide Severity Rating Scale (C-SSRS) score \> 2,
- ✕ 4. function limitation precluded the meditation practice,
- ✕ 5. participated meditation program before,
- ✕ 6. any other conditions/contraindications that prohibit the application of taVNS including but not limited to any current or past history of cardiovascular disorders, recent ear trauma, and metal implants above the level of the neck,
- ✕ 7. no access to the internet.
Where it's recruiting
Florida
Tallahassee
Source: ClinicalTrials.gov · NCT07415941 · last updated 2026-03-25