Mindfulness Training During Accelerated TMS for Depression
Eligible age
18–80 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
This NIH-funded single-arm pilot tests the feasibility, acceptability, and preliminary effects of embedding brief guided mindfulness practice (via the Waking Up smartphone app) into the inter-session intervals of clinically administered accelerated intermittent theta-burst stimulation (aiTBS) for major depressive disorder (MDD). Participants receive aiTBS as standard clinical care at MUSC; the research intervention is daily guided mindfulness practice during the aiTBS course. Outcomes include feasibility/acceptability, changes in state mindfulness and hedonic tone (Day 0 to Day 5), perceived ease of meditation, trait mindfulness at 4 and 12 weeks, and durability of antidepressant response (PHQ-9) at 4 and 12 weeks.
Sponsor: Medical University of South Carolina
You may qualify if…
- ✓ Clinical diagnosis of MDD and eligible for aiTBS at MUSC
- ✓ Already enrolled in aiTBS course at MUSC
- ✓ English proficiency
- ✓ Smartphone or willingness to use study-provided device
You may not qualify if…
- ✕ TMS contraindications (e.g., seizure history, implants, pregnancy)
- ✕ Concurrent neuromodulation (ECT, VNS)
- ✕ Psychotic disorder, bipolar disorder, active substance use disorder, high suicide risk
- ✕ Unable/unwilling to engage in mindfulness or complete questionnaires
Where it's recruiting
Charleston
Source: ClinicalTrials.gov · NCT07369557 · last updated 2026-06-17