IMST for Dementia Risk Reduction
Eligible age
60–80 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
Using a 2-arm, RCT approach, the primary goal of the study is to evaluate the feasibility and preliminary efficacy of Inspiratory Muscle Strength Training (IMST) as a non-pharmacologic intervention to reduce cardiovascular and cognitive risks in older adults. Next, investigators will examine secondary effects of IMST on mood, sleep quality, systemic inflammation, and physical/motor function. Finally, investigators will assess participant adherence and acceptability ratings of using an 8-week home-based IMST protocol in a diverse older adult sample.
Sponsor: Florida State University
You may qualify if…
- ✓ Ages 60-80
- ✓ Converted telephone MoCA total score≥18
- ✓ Presence of at least one dementia risk factor (e.g., MCI or subjective cognitive decline, hypertension \[SBP \>130 mmHg or on medication\], sedentary lifestyle \[\<150 min/week\], family history of dementia or self-reported APOE ε4 carrier, or mild sleep-disordered breathing; CAIDE total score \[\>5\]
- ✓ Capable of independently completing or requiring minimal assistance with inspiratory muscle strength training (IMST)
- ✓ Willing to adhere to the IMST protocol (approximately 5-10 minutes per day for 8 weeks)
- ✓ Optional inclusion of inspiratory muscle weakness (MIP \<80 cmH₂O for men, \<70 cmH₂O for women) will also be assessed.
You may not qualify if…
- ✕ tMoCA \<18, or diagnosis of neurodegenerative illness at the discretion of principal investigator (except MCI)
- ✕ Current evidence of any major psychiatric disorder including psychosis (at the discretion of principal investigator), bipolar disorder, severe major depression (PHQ-9 \> 20)
- ✕ Unstable cardiovascular or pulmonary disease
- ✕ Recent respiratory therapy or major medication changes
- ✕ Self-reported severe untreated or unstable obstructive sleep apnea (OSA)
- ✕ Recent start (within the past month) of CPAP or BiPAP, or recent use of inspiratory muscle training
- ✕ Lung and eardrum injuries
- ✕ Non-English speaking
Where it's recruiting
Tallahassee
Source: ClinicalTrials.gov · NCT07349706 · last updated 2026-03-27