Individual Differences in Gait and Osteoarthritis Pain
Eligible age
45–80 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The goal of this observational study is to look at inter-individual differences in knee osteoarthritis (OA) walking pain and performance. The main questions this study aims to answer are: Why do some people with knee osteoarthritis have more severe disabling pain than others, even though the degenerative changes in their knees are similar? What are the factors that contribute to walking pain in people with knee osteoarthritis? Participants will complete surveys, perform physical function tasks, get a knee X-ray and MRI, undergo non-invasive brain imaging, and undergo sensory testing.
Sponsor: University of Pittsburgh
You may qualify if…
- ✓ Knee pain for greater than 6 months.
- ✓ Moderate-to-severe knee pain (\>3/10) due to osteoarthritis, as defined by American College of Rheumatology and EULAR diagnostic criteria, on \>50% of days in the past month.
- ✓ KL grade 2-4 indicating significant degenerative changes on knee X-ray.
- ✓ 45-80 years old
You may not qualify if…
- ✕ Inflammatory arthritis (e.g. rheumatoid arthritis).
- ✕ More intense pain due to another chronic pain syndrome (e.g. fibromyalgia, hip osteoarthritis)
- ✕ Significant pain or weakness in the lower extremities due to a neurological condition (e.g. lumbar radiculopathy, paresis due to stroke)
- ✕ Acute pain that is more intense than knee osteoarthritis pain
- ✕ Current routine use of more than 15 mg oral morphine equivalents per day (use of \<15 mg OME does not exclude the participant).
- ✕ Recent new medication, exercise, behavioral, or complementary and integrative treatment started in the last month. Stable use of these treatments for greater than 1 month does not exclude the participant.
- ✕ Recent intra-articular injection of steroid or other agent (greater than 1 month does not exclude the participant)
- ✕ Recent knee radiofrequency ablation (greater than 3 months does not exclude the participant)
Where it's recruiting
Pittsburgh
Source: ClinicalTrials.gov · NCT07308873 · last updated 2026-01-29