Restoration of Consciousness With Ultrasonic Deep Brain Stimulation During Anesthetic Sedation
Eligible age
18–40 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
The purpose of this study is to see if mental functions take place during different levels of anesthesia using two commonly used drug (propofol and dexmedetomidine) and will include low-intensity focused ultrasound pulsation (LIFUP) to stimulate specific areas of the brain while undergoing functional Magnetic Resonance Imaging (fMRI or "brain imaging"), which shows areas in the brain involved in thinking at different depths of anesthesia. That is, ultrasound is being used to stimulate the brain and multiple pictures will be taken of the brain. As a result of this study, we expect to gain a deeper understanding of mental function during different levels of anesthesia, and to evaluate if the use of ultrasonic brain stimulation accelerates return to consciousness.
Sponsor: University of Michigan
You may qualify if…
- ✓ Healthy study participants with American Society of Anesthesiologists (ASA) Physical Status Classification System-1 status
- ✓ The participants will be right-handed adults
- ✓ Body mass index (BMI) less than 30.
- ✓ All subjects will be English speakers.
You may not qualify if…
- ✕ Medical contraindication to MRI scanning; are unable to undergo MRI scanning because of possible pregnancy or currently breastfeeding,
- ✕ BMI\>30,
- ✕ metallic substances in the body, claustrophobia, anxiety, or cardiopulmonary disease; or have an intracranial structural abnormality on T1-weighted MRI scans.
- ✕ History of allergy to propofol, dexmedetomidine, any components of propofol or dexmedetomidine, eggs or egg products, soybean or soybean products,
- ✕ Neurological, cardiovascular, or pulmonary illness;
- ✕ Significant head injury with loss of consciousness;
- ✕ Learning disability or other developmental disorder; sleep apnea or any severe snoring history; gastroesophageal reflux disease (GERD) or heartburn; pancreatitis or a history of pancreatitis, or sensory/motor loss sufficient to interfere with performance of the study; epilepsy/seizure disorder (including a history of seizures) or stroke (including a history of stroke).
- ✕ Participants with tattoos in the head or neck region will be excluded from study; other tattoos are subject to determination by investigators based on their assessment regarding participant safety.
Where it's recruiting
Ann Arbor
Source: ClinicalTrials.gov · NCT07221539 · last updated 2025-10-28