A Study to Learn About Study Medicine Called PF-08049820 in People With Eczema
Eligible age
18–64 yrs
Accepts
All genders
Locations
4 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The purpose of this study is to learn if the study medicine (PF-08049820) is safe and effective for the treatment of atopic dermatitis (AD), also known as eczema, or atopic eczema. People with this condition may have severe itching and rashes on the skin. The study is seeking participants who: 1. Are 18 to 64 years of age; 2. Were confirmed to have AD at least 6 months ago; 3. Do not have a suitable prescribed medicine for AD; 4. Are considered by their doctors to have moderate to severe AD. The study has two stages (Stage 1 and Stage 2). In both stages, eligible participants will take either PF-08049820 or placebo as tablets by mouth daily for 12 weeks. A placebo does not have any medicine in it but looks just like the medicine being studied. Participants will visit the clinic on Day 1, Weeks 1, 2, 4, 6, 8 and 12. They will have a follow-up visit at Week 16. During this time, the participant's health and skin condition will be checked. They will have blood and urine tests. They will also have to answer questions about their health, skin condition, and how much their skin condition affects their lives. The experiences of participants receiving the study medicine will be compared to those receiving placebo. This will help to understand if PF-08049820 is safe and effective.
Sponsor: Pfizer
You may qualify if…
- ✓ Participants must meet the following criteria:
- ✓ 1. Are 18 to 64 years of age
- ✓ 2. Have clinical diagnosis of AD for at least 6 months prior to Day 1 and have diagnosis of AD confirmed by photographs
- ✓ 3. Have moderate to severe AD as defined by the following at screening and baseline visits:
- ✓ Affected body surface area (BSA) greater than or equal to 10% and up to 60%;
- ✓ Validated Investigator's Global Assessment (vIGA) greater than or equal to 3;
- ✓ Eczema Area and Severity Index (EASI) greater than or equal to 16;
- ✓ AND
You may not qualify if…
- ✕ Participants must not meet the following criteria:
- ✕ 1. Have an infection that requires treatment
- ✕ 2. Have other skin conditions other than AD
- ✕ 3. Have severe uncontrolled asthma
- ✕ 4. Regular use (more than 2 visits per week) of a tanning booth or phototherapy for AD within 4 weeks of the screening visit
Where it's recruiting
Huntington Beach · Los Angeles · Northridge · Santa Monica
Margate · Miami
The Bronx
Pittsburgh
Source: ClinicalTrials.gov · NCT07216027 · last updated 2026-07-28