RecruitingParkinson Disease
Effects of Transcranial Focused Ultrasound Stimulation (tFUS) on Neurological and Cognitive Outcomes in Parkinson's Disease
Eligible age
22–80 yrs
Accepts
All genders
Locations
4 states
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
This is a pilot randomized, sham-controlled, double-blind, multi-center study evaluating the safety and preliminary effectiveness of the Gen0Bh Transcranial Focused Ultrasound System for the treatment of motor symptoms in individuals with idiopathic Parkinson's disease.
Sponsor: Sanmai Technologies PBC dba Sanmai
You may qualify if…
- ✓ Adults aged 22 to 80 years.
- ✓ Diagnosis of idiopathic Parkinson's disease.
- ✓ MDS-UPDRS Part III score ≥25 in OFF-medication state at baseline.
- ✓ Stable dopaminergic therapy for at least 30 days prior to enrollment.
- ✓ English proficiency.
- ✓ Normal or corrective hearing and vision.
- ✓ Ability to provide informed consent (or availability of an LAR) and comply with protocol requirements.
You may not qualify if…
- ✕ Atypical or secondary Parkinsonism.
- ✕ Prior deep brain stimulation or intracranial surgery.
- ✕ MoCA score \<23.
- ✕ Severe psychiatric illness (e.g., psychosis, suicidality, untreated major depression).
- ✕ History of seizure or intracranial pathology.
- ✕ Significant neurologic disease (e.g. brain tumor, multiple sclerosis)
- ✕ Contraindication to MRI or ultrasound.
- ✕ Unstable systemic medical conditions.
Where it's recruiting
Source: ClinicalTrials.gov · NCT07207122 · last updated 2026-07-31