Genetic Variation in IgG in Alpha 1 Antitrypsin Deficiency
Eligible age
19+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The goal of this study is to learn whether patients who have a genetic mutation in the genes that cause alpha 1 antitrypsin deficiency also have genetic variation in nearby genes that can increase risk for reduced immune function and respiratory infections. To investigate this hypothesis, we will compare immune responses to the 20-valent pneumococcal conjugate vaccine (PCV20, Pfizer) between participants who have one abnormal copy of the SERPINA1 gene and either no COPD exacerbations, vs those with 2 or more COPD exacerbations in the past year.
Sponsor: University of Alabama at Birmingham
You may qualify if…
- ✓ Adults who are heterozygous for a SERPINA1 Z allele
- ✓ Have either had no COPD exacerbations or 2 or more exacerbations in the previous year
- ✓ Has not received a pneumococcal conjugate vaccine within the past 5 years, or has only received the pneumococcal polysaccharide vaccine in the past
You may not qualify if…
- ✕ Received a pneumococcal conjugate vaccine within the past 5 years
- ✕ Known allergy, severe adverse reaction, or other sensitivity to pneumococcal conjugate vaccines
Where it's recruiting
Birmingham
Source: ClinicalTrials.gov · NCT07135427 · last updated 2025-11-10