IOA Preventing Occlusal Changes With MAD Use
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
This study is evaluating two standard-of-care strategies used to prevent bite changes (occlusal changes) in patients treated with a Mandibular Advancement Device (MAD) for sleep-related breathing disorders such as obstructive sleep apnea (OSA). While MAD therapy is effective, it can lead to changes in how the teeth fit together, including the development of a posterior open bite. Participants in this study will be randomly assigned to one of two standard-of-care approaches: using an interocclusal aligner each morning after removing the MAD, or performing daily jaw exercises. Both methods aim to reduce the risk of occlusal changes. The study will follow participants over a 3-month period and includes dental evaluations, 3D oral scans, and short daily surveys. Findings from this research may help guide best practices for preserving occlusion during MAD therapy.
Sponsor: Isabel Moreno Hay
You may qualify if…
- ✓ adult participants (≥18 years)
- ✓ diagnosed with SRBD and prescribed Mandibular Advancement Device (MAD) therapy
- ✓ Participants will include patients with well restored natural dentition with all posterior teeth, excluding third molars, one missing premolar secondary to orthodontic treatment.
You may not qualify if…
- ✕ pervious orthognathic surgery
- ✕ anterior cross bite
- ✕ posterior cross bite
- ✕ existing open bite or implant supported restorations
- ✕ tooth mobility
- ✕ significant dental caries or periodontitis
- ✕ severe bruxism
- ✕ planned upcoming dental work including caps, crowns, implants, or braces
Where it's recruiting
Lexington
Source: ClinicalTrials.gov · NCT07103941 · last updated 2026-05-18