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RecruitingMetabolic SyndromeHealthy ParticipantsMetabolically Healthy Obesity

Impact of Supplemental Fiber on Gut and Vascular Health Related in Obesity Phenotypes

Eligible age

18–55 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

Yes

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About this study

Based on prior research, the investigators are interested in whether an intervention targeting gut health (supplemental fiber for 9 weeks total) will improve vascular health in individuals with obesity. Additionally, the investigators are interested in if this response differs based on whether individuals with obesity have very few heart disease risk factors or several heart disease risk factors.

Sponsor: Ball State University

You may qualify if…

  • Participants are 18-55 years old.
  • Participants BMI is ≥30 kg/m2 - this BMI requirement is due to our research aims.
  • Participants have either 0-1 or 2+ of the following risk factors outside of the normal reference ranges: blood pressure, blood sugar, triglycerides, and HDL-cholesterol.
  • Participants are not pregnant or expecting to become pregnant (females only). •Participants are not postmenopausal (females only).
  • Participants have not been diagnosed with an advanced cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes).
  • Participants have not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease, diverticulosis/diverticulitis).
  • Participants do not regularly take anti-inflammatory drugs (more than 2x week) and are willing to suspend use of these medications for 3 days leading up to in-lab visits.
  • Participants do not take weight-loss medications (e.g., Ozempic, Wegovy).

You may not qualify if…

  • Participants are not 18-55 years old.
  • Participants BMI is not ≥30 kg/m2 - this BMI requirement is due to our research aims.
  • Participants do not have either 0-1 or 2+ of the following risk factors outside of the normal reference ranges: blood pressure, blood sugar, triglycerides, and HDL-cholesterol.
  • Participants are pregnant or expecting to become pregnant (females only).
  • Participants are postmenopausal (females only).
  • Participants have been diagnosed with an advanced cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes).
  • Participants have been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease, diverticulosis/diverticulitis). •Participants regularly take anti-inflammatory drugs (more than 2x week) and are not willing to suspend use of these medications for 3 days leading up to in-lab visits.
  • Participants take weight-loss medications (e.g., Ozempic, Wegovy).

Where it's recruiting

Indiana

Muncie

Source: ClinicalTrials.gov · NCT07095426 · last updated 2025-07-31

Impact of Supplemental Fiber on Gut and Vascular Health Related in Obe · TrialPath