Accelerated Treatment for Co-occurring Insomnia, Nightmares, and PTSD
Eligible age
18–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
This study is a two-arm individually randomized group treatment clinical trial evaluating behavioral therapies for insomnia, nightmares, and PTSD. The study will compare cognitive-behavioral therapy for insomnia and nightmares to sleep hygiene (Control), both integrated with Written Exposure Therapy for PTSD and delivered in an accelerated (i.e., 5-day) group treatment format, preceded and followed by individual treatment sessions. 160 participants will be randomized into one of two study conditions.
Sponsor: Palo Alto Veterans Institute for Research
You may qualify if…
- ✓ 1. Defense Enrollment Eligibility Reporting System (DEERS) eligible active-duty military personnel or veteran, 18-65 years old.
- ✓ 2. Ability to speak and read English.
- ✓ 3. Clinically significant PTSD symptoms (CAPS-5 \> 25 with at least one Intrusion symptom and at least one Avoidance symptom).
- ✓ 4. Clinically significant symptoms of insomnia disorder (Structured Clinical Interview for Sleep Disturbance DSM-5 (SCISD) Insomnia Criteria are met and Insomnia Severity Index (ISI) \> 11).
- ✓ 5. Nightmares \> 1 monthly (as reported on the SCISD).
- ✓ 6. Willing to refrain from new behavioral health or medication treatment for issues pertaining to PTSD, sleep, and nightmares during study participation.
You may not qualify if…
- ✕ 1. Current suicide or homicide risk meriting crisis intervention.
- ✕ 2. Inability to comprehend the baseline screening questionnaires.
- ✕ 3. Unwilling to remain abstinent from alcohol during therapy sessions.
- ✕ 4. Serious mental health symptoms, such as mania, psychosis, alcohol or substance use disorders warranting immediate clinical attention based on interviewer assessment and clinical judgement.
- ✕ 5. Currently engaged in evidence-based psychotherapy for PTSD (e.g., Prolonged Exposure Therapy, Cognitive Processing Therapy, Written Exposure Therapy) or insomnia or nightmares (e.g., Cognitive Behavioral Therapy for Insomnia or Nightmares).
- ✕ 6. Pregnancy, as determined by self-report, because pregnancy can adversely affect sleep outside of PTSD, insomnia, and nightmares.
- ✕ 7. Working duty shifts ending later than 21:00 or starting before 05:30 more than 2 times per month.
Where it's recruiting
Kileen
Source: ClinicalTrials.gov · NCT07069517 · last updated 2025-12-03