The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity
Eligible age
18–75 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
This research study wants to learn about Chronic Kidney Disease (CKD) with Obesity, and Heart Failure with preserved Ejection Fraction (HFpEF) and better ways to evaluate these diseases. HFpEF means that the heart is not able to fill properly with blood while it is resting so the amount of blood pumped out to the body is less than it would be if it was filling properly. The study is being done to describe the differences in how the kidneys handle protein and salt in participants with HFpEF and obesity compared to healthy persons.
Sponsor: University of Mississippi Medical Center
You may qualify if…
- ✓ Adults 18-75 years old
- ✓ Normal kidney function
- ✓ No heart failure
- ✓ BMI 25-30kg/m2
- ✓ Adults 18-75 years old
- ✓ eGFR \>= 60 mL/min/1.73m2
- ✓ BMI \> 35 kg/m2
- ✓ Adults 18-75 years old
You may not qualify if…
- ✕ Diagnosis of chronic illness
- ✕ eGFR\<60mL/min/1.73m2
- ✕ Pregnancy or breast feeding
- ✕ History of cutaneous or allergic reaction to iodine-based products of contrast dyes
- ✕ Hemoglobin levels \<7mg/dL
- ✕ Acute illness or hospitalization event within 3 months
- ✕ Unable to stop NSAIDs
- ✕ Comorbid conditions: MM, amyloidosis, pheochromocytoma, SCD, metastatic brain lesions, advanced kidney disease, liver dysfunction, endotoxemia, hyperthyroidism
Where it's recruiting
Jackson
Source: ClinicalTrials.gov · NCT07052539 · last updated 2025-07-04