RecruitingMild Traumatic Brain InjuryPost Concussion Syndrome
Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline
Eligible age
20–85 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain. The modulated blood flow will restore the flow of cerebrospinal fluid (CSF) and this in turn can help improve waste clearance in the brain and prevent build up that may lead to disease.
Sponsor: University of Wisconsin, Madison
You may qualify if…
- ✓ Age 20-85 years
- ✓ Willing and able to undergo all procedures
- ✓ Free of any neurological (e.g., epilepsy, stroke, Parkinson's, brain tumors, moderate or severe traumatic brain injury), neuropsychiatric (e.g., schizophrenia, substance abuse, clinical depression), or developmental (e.g., autism, ADHD) or any other medical condition at the discretion of the PI and co-investigators
- ✓ Age 20-65
- ✓ Diagnosed with mild traumatic brain injury and be within 1-52 weeks post-injury
- ✓ Willing and able to undergo all procedures
You may not qualify if…
- ✕ Contraindication to MRI
- ✕ Known allergies to common electrode materials
- ✕ Contraindications for MRI
- ✕ Known allergies to common electrode materials
- ✕ Candidates currently on cardiovascular medications which, in the opinion of the investigators, would introduce a confounding factor to glymphatic system function (i.e. ACE-inhibitors, angiotensin receptor blockers, calcium channel blockers)
- ✕ Candidates who have chronic infectious diseases (e.g. hepatitis, HIV, TB)
- ✕ Candidates diagnosed with small vessel disease, vascular associated dementia (e.g. VCID), or renal disease
- ✕ Candidates retinopathies or neuropathies that, in the opinion of the investigators, would prevent them from being able to complete the study or would introduce a confounding factor to glymphatic system function
Where it's recruiting
Wisconsin
Madison
Source: ClinicalTrials.gov · NCT07044596 · last updated 2026-05-06