RecruitingUnipolar Depression
Transcranial Direct Current Stimulation for Depression
Eligible age
22+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
This study will test the efficacy of transcranial direct current stimulation (tDCS) combined with mindfulness, remotely-delivered using a telemedicine protocol in 25 adults with unipolar depression.
Sponsor: Soterix Medical
You may qualify if…
- ✓ Clinically stable patients that meet criteria for diagnosis of MDD according to DSM-V-TR and confirmed with the Mini International Neuropsychiatric interview
- ✓ Currently experiencing a major depressive episode of at least 4 week's duration as part of a unipolar depression
- ✓ QIDS-SR score \>11 on all three days of screening week (Days 1,3, 7)
- ✓ Scored at least 17 (inclusive) on the HDRS-17 at trial entry
- ✓ Any antidepressant medication is stable ≥ 30 days prior to HDRS-17 screening
- ✓ Female patients are allowed if not pregnant and using a medically acceptable method of contraception, if of childbearing potential.
You may not qualify if…
- ✕ Failure to respond to at least 2 antidepressant medications
- ✕ Drug or alcohol abuse or dependence in the preceding 3 months
- ✕ Concurrent benzodiazepine medication
- ✕ High suicide risk assessed during clinician screening at baseline interview.
- ✕ Failure to respond to ECT treatment or rTMS treatment in this or any previous episode.
- ✕ Current DSM-V-TR psychotic disorder
- ✕ History of clinically defined neurological disorder or insult that may impact participation in this study as determined by study physician
- ✕ Metal in the cranium or skull defects
Where it's recruiting
New Jersey
Woodbridge
Source: ClinicalTrials.gov · NCT07042217 · last updated 2025-11-10