RecruitingLSDMajor Depressive DisorderDepression
Mood Effects of Serotonin Agonists: Depression
Eligible age
18–40 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression. The investigators will assess the relationship between mood-related symptoms and EEG as a neurophysiological marker.
Sponsor: University of Chicago
You may qualify if…
- ✓ English Fluency
- ✓ high school education or higher
- ✓ BMI between 19-30 kg/m2
You may not qualify if…
- ✕ individuals with a medical condition contraindicating study participation as determined by the study physician (e.g., liver disease, abnormal EKG, liver or cardiovascular disease)
- ✕ high blood pressure (\>140/90)
- ✕ current suicidal ideation or suicide attempt in past 12 months
- ✕ past year severe substance use disorder
- ✕ personal or first-degree relative with history of psychosis
- ✕ currently taking any psychiatric medication (for conventional antidepressants must be off for ≥ 2 weeks)
- ✕ active panic disorder
- ✕ severe obsessive-compulsive disorder
Where it's recruiting
Illinois
Chicago
Source: ClinicalTrials.gov · NCT07017478 · last updated 2025-07-03