RecruitingPost Operative Atrial FibrillationAtrial Fibrillation, Postoperative

BoxX-NoAF Clinical Trial

Eligible age

65+ yrs

Accepts

All genders

Locations

10 states

Healthy volunteers

Yes

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About this study

Post Operative Atrial Fibrillation (POAF) is the most common complication of cardiac surgery. POAF incidence can exceed 50% depending on the patient baseline characteristics and surgery type. Patients with POAF tend to have worse acute and long-term clinical outcomes. BoxX-NoAF is a randomized trial to evaluate if prophylactic ablation and exclusion of the Left Atrial Appendage at the time of other routine cardiac surgery can reduce the incidence of post operative AF and clinical AF during long term follow up in patients who have not yet developed AF but are at risk.

Sponsor: AtriCure, Inc.

You may qualify if…

✓ Planned and clinically indicated for cardiac surgical procedure requiring cardiac bypass and opening of the pericardium
✓ Age ≥ 65 years and CHA2DS2-VASc ≥ 3

You may not qualify if…

✕ Documented history of atrial fibrillation or atrial flutter anytime prior to the cardiac surgery
✕ Prior procedure involving opening the pericardium or entering the pericardial space
✕ Patients undergoing off-pump surgery
✕ Prior LAA occlusion, exclusion, or removal (surgical or percutaneous)
✕ Presence of a permanent pacemaker
✕ Infiltrative cardiomyopathies (i.e. amyloidosis)
✕ Planned cardiac surgical procedure using non-sternotomy approaches
✕ Patients whose planned procedure is a heart transplant or implantation of any long-term ventricular assist devices