Remote Electrical Stimulation as a Long-term Intervention for Endometriosis Flare Ups
Eligible age
22–45 yrs
Accepts
Women
Locations
1 state
Healthy volunteers
No
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About this study
The goal of this clinical trial is to learn if a wearable brain stimulation device called NettleEndo can reduce chronic pelvic pain and improve wellbeing in women with endometriosis. The study also aims to assess the safety and usability of the device when used at home over several months. The main questions it aims to answer are: 1. Does at-home transcranial direct current stimulation (tDCS) reduce daily pain intensity in women with endometriosis? 2. Does the device also improve mood and sleep quality? Researchers will compare two groups-one receiving active brain stimulation and one receiving a sham (placebo) stimulation-to see if the active device provides greater improvements in symptoms. Participants will: 1. Use the NettleEndo device at home for 20 minutes per session, five times per week for 12 weeks 2. Be randomly assigned to receive either real or sham stimulation through the device 3. Complete daily and weekly symptom ratings through a mobile app 4. Be followed for 90 days after completing the intervention to monitor longer-term effects All activities are completed remotely using a smartphone app. Participants can contact the study team with questions at any time. The study is double-blind, meaning neither participants nor the researchers assessing outcomes will know who received active or sham treatment until the end of the trial.
Sponsor: Samphire Group, Inc.
You may qualify if…
- ✓ Female, 22-45 years old
- ✓ Assigned female at birth
- ✓ Fluent in English
- ✓ Capacity to consent
- ✓ Confirmed diagnosis of endometriosis by a qualified physician, via:
- ✓ Laparoscopic surgery with biopsy-proven endometriosis, OR
- ✓ Clear evidence of ovarian endometrioma or deep infiltrating endometriosis on ultrasound/MRI
- ✓ Pain levels:
You may not qualify if…
- ✕ Pregnancy/breastfeeding or planning to become pregnant in next 6 months
- ✕ History of epileptic neurological conditions in the immediate family
- ✕ Severe/untreated neurological disease (e.g., epilepsy or seizure disorders, stroke or transient ischemic attack \[TIA\], subarachnoid hemorrhage, traumatic brain injury \[TBI\] with persistent neurological deficits, brain tumors \[malignant or benign\], multiple sclerosis, Parkinson's disease, Alzheimer's disease or other dementias, Huntington's disease, cerebral aneurysms or arteriovenous malformations \[AVMs\], active central nervous system infections \[e.g., meningitis, encephalitis\], hydrocephalus, other neurodegenerative diseases not otherwise specified, or any other neurological condition that, in the opinion of the principal investigator, may increase risk or interfere with study participation or outcomes)
- ✕ Metal implants/electronic devices in brain, head, or neck area
- ✕ Participating in any other clinical trial
- ✕ History of stroke, brain surgery, tumors, head trauma
- ✕ Active skin lesions, open wounds, cuts, or infections on the scalp
- ✕ Active scalp conditions (dermatitis, eczema, psoriasis)
Where it's recruiting
San Francisco
Source: ClinicalTrials.gov · NCT06974773 · last updated 2025-12-18