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RecruitingOsteoarthritis, Knee

Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

Eligible age

50–100 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

No

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About this study

The primary aim of this study is to investigate whether low-dose radiotherapy is an effective treatment to reduce the pain of knee osteoarthritis. A secondary aim is to determine whether patients experience any more measurable side effects than those receiving sham treatments.

Sponsor: Mayo Clinic

You may qualify if…

  • ✓ • patient's primary care provider is at Mayo Clinic in Rochester, MN
  • ✓ age 50-100 years
  • ✓ ICOAP pain scale A1 at least moderate intensity or B6 at least moderate intensity
  • ✓ diagnosed with primary knee OA ICD-10 codes M17.x
  • ✓ o You have not had recurrent episodes of sudden onset of warmth, redness, or swelling of the affected knee
  • ✓ physical exam findings of medial or lateral joint line tenderness on palpation that is in the same location as the knee pain.
  • ✓ absence of primary knee pain in the pes anserine or hamstring or gastrocnemius, quadriceps, or patellar tendons on exam.
  • ✓ radiographic Kellgren-Lawrence grade 2-3 on 4-view knee x-rays taken within the last year ability to complete surveys electronically by email

You may not qualify if…

  • ✕ • Kellgren-Lawrence grade 1 or 4
  • ✕ pregnancy or women 54 years and younger with potential for pregnancy (if they or their partner have not had tubal ligation, hysterectomy, or vasectomy)
  • ✕ history of ipsilateral intraarticular knee surgery
  • ✕ use of injected corticosteroids within 3 months or hyaluronans within 6 months or within 1 month if there was no sustained improvement post-injection of either corticosteroid or hyaluronan.
  • ✕ history of trauma to this knee in the last year that clearly caused the pain now present
  • ✕ history of RA, gout, pseudogout, hemarthroses (eg, hemophilic arthropathy) or other inflammatory arthritis involving this knee
  • ✕ history of symptomatic hip OA
  • ✕ history of psychosis, personality disorder, uncontrolled affective disorder

Where it's recruiting

Minnesota

Rochester

Source: ClinicalTrials.gov · NCT06887829 · last updated 2026-06-12

Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial · TrialPath