RecruitingPeritoneal Dialysis, Heart Failure
Exploring Water-free Sodium Storage
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
The overarching goal of this proposal is to definitively establish if acute water free Na storage and release occurs, if the amount stored/released is of a quantity that is physiologically relevant, and if the location is intracellular vs. extracellular.
Sponsor: Yale University
You may qualify if…
- ✓ ESRD Patients actively undergoing PD with a reliably functioning PD catheter
- ✓ Systolic blood pressure \> 130 mmHg
- ✓ Serum sodium \>135 mmol/L
- ✓ daily urine output \< 400ml
- ✓ stable PD prescription for at least 2 months without requirement of 4.25% glucose PD solution
- ✓ PD vintage of at least 6 months
- ✓ Euvolemic as defined by the patient at their dry weight and free of any signs or symptoms of volume overload, per referring nephrologist
You may not qualify if…
- ✕ Poorly controlled diabetes with hemoglobin A1C\>9%
- ✕ 1 or more episodes of peritonitis in the previous 6 months or active infection of the peritoneal dialysis catheter
- ✕ Anemia with hemoglobin \<8g/dL
- ✕ Inability to give written informed consent or follow study protocol.
- ✕ Urinary incontinence
- ✕ Body weight \< 60kg
- ✕ gastrointestinal disease that causes diarrhea or expectation of sodium losses in stool.
- ✕ use of amiodarone in the last 6 months (which will interfere with tissue iodine ascertainment).
Where it's recruiting
Connecticut
New Haven
Source: ClinicalTrials.gov · NCT06872645 · last updated 2026-05-13