RecruitingSpinal Cord Injury

The International Spinal Cord Injury Blood Biomarker Longitudinal Evaluation (I-SCRIBBLE) Study

Eligible age

19+ yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

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About this study

To determine the accuracy of serum NF-L and GFAP levels (ie the biomarkers) at different time points postinjury for predicting the severity of neurologic impairment at 6 months postinjury as either motor complete (AIS grade A/B) or motor incomplete (AIS grade C/D) a group of patients who suffer traumatic spinal fracture and/or dislocation of the spinal column but without neurologic injury will be enrolled as non-SCI spine trauma control participants.

Sponsor: AO Foundation, AO Spine

You may qualify if…

✓ Age ≥ 19 years
✓ Blunt (non-penetrating) traumatic SCI
✓ Baseline neurologic impairment deemed "complete" (AIS grade A) or "incomplete" (AIS grade B, C, or D) based on clinical history/examination and/or diagnostic imaging
✓ Bony spinal level involvement between C0 and L1, inclusive
✓ Ability to have initial blood sample drawn within 24 hours of injury
✓ Treated either surgically or non-surgically
✓ Ability to provide informed consent according to the IRB/EC defined and approved procedures
✓ Age ≥ 19 years

You may not qualify if…

✕ Penetrating SCI (eg, gunshot, stab)
✕ Previous SCI
✕ Isolated spinal injury below L1
✕ Isolated radiculopathy without fracture
✕ Isolated cauda equina injury
✕ Patients with known diagnosis of multiple sclerosis
✕ Preexisting thromboembolic disease or coagulopathy (disorders related to blood clotting), such as hemophilia or von Willebrand disease
✕ Patients who in the investigator's opinion will not be compliant with the study procedures and patients who have any other conditions/injuries that in the investigator's opinion would render the study procedures dangerous

Where it's recruiting

Wisconsin

Milwaukee

Source: ClinicalTrials.gov · NCT06839300 · last updated 2026-05-05