RecruitingTurner SyndromePrimary Ovarian Insufficiency (Poi)
Bleeding Patterns in Sequential and Continuous Progesterone Supplementation in Adolescents With Turner Syndrome
Eligible age
12–20 yrs
Accepts
Women
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
This is a single-site open label non-randomized study comparing effects of sequential versus continuous use of progesterone supplementation amongst Turner Syndrome (TS) patients with primary ovarian insufficiency (POI) prescribed hormone replacement therapy (HRT).
Sponsor: Children's Mercy Hospital Kansas City
You may qualify if…
- ✓ Diagnosis of Turner Syndrome and Primary Ovarian Insufficiency.
- ✓ Prescribed adult dosing\* of transdermal or oral estradiol for estrogen replacement therapy.
- ✓ \*Adult dosing of will be defined per published clinical practice guidelines from the 2023 International Turner Syndrome Meeting (i.e. 50-200μg/day of transdermal estradiol, or (i.e. 50-200μg/day of transdermal estradiol or 2-4mg/day oral estradiol).
- ✓ Have achieved menarche.
You may not qualify if…
- ✕ Disclosure of sexual activity and desire for contraception.
- ✕ Having a levonorgestrel-releasing intrauterine device or etonogestrel arm implant in place.
- ✕ Having received depot medroxyprogesterone within one year prior to study recruitment.
- ✕ Non-English or non-Spanish speaking.
Where it's recruiting
Missouri
Kansas City
Source: ClinicalTrials.gov · NCT06834594 · last updated 2025-09-04