RecruitingOvarian CancerFallopian Tube CancerPrimary Peritoneal Cancer

A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)

Eligible age

18+ yrs

Accepts

Women

Locations

21 states

Healthy volunteers

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About this study

The main goals of this study are to learn about the safety of sacituzumab tirumotecan with bevacizumab and if people tolerate it; and if people who take sacituzumab tirumotecan with or without bevacizumab live longer without the cancer getting worse than those who receive standard of care treatment.

Sponsor: Merck Sharp & Dohme LLC

You may qualify if…

✓ Has histologically confirmed Federation of Gynecology and Obstetrics (FIGO) Stage III or IV epithelial ovarian, primary peritoneal, or fallopian tube carcinoma of certain histologies
✓ Has received 4 or more cycles of platinum-based doublet chemotherapy in first-line and a total of 6 cycles of carboplatin-based doublet chemotherapy in second-line setting for ovarian cancer (OC)
✓ Has platinum-sensitive epithelial OC
✓ Has provided tissue of a tumor lesion that was not previously irradiated
✓ Human immunodeficiency virus (HIV)-infected participants must have well controlled HIV on antiretroviral therapy
✓ Participants who are hepatitis B surface antigen positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy for at least 4 weeks, and have undetectable HBV viral load prior to allocation (Part 1) or randomization (Part 2)
✓ Participants with a history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable at screening
✓ Has an ECOG performance status of 0 or 1 assessed within 7 days before allocation (Part 1) or randomization (Part 2)

You may not qualify if…

✕ Has nonepithelial cancers (germ cell tumors and sex cord-stromal tumors), low-grade serous tumors, low-grade endometrioid tumors, borderline tumors (low malignant potential), mucinous, seromucinous that is predominantly mucinous, malignant Brenner's tumor and undifferentiated carcinoma
✕ Has platinum-resistant OC or platinum-refractory OC
✕ Has history of documented severe dry eye syndrome, severe Meibomian gland disease and/or blepharitis, or severe corneal disease that prevents/delays corneal healing
✕ Has active inflammatory bowel disease requiring immunosuppressive medication or previous history of inflammatory bowel disease (e.g. Crohn's disease, ulcerative colitis, or chronic diarrhea)
✕ Has uncontrolled, significant cardiovascular disease or cerebrovascular disease
✕ Has a history of (noninfectious) pneumonitis/interstitial lung disease (ILD) that required steroids or has current pneumonitis/ILD
✕ HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease
✕ Has received more than 2 prior lines of systemic therapy for OC