RecruitingTransgender Women
Progesterone in Gender Affirming Hormone Therapy Study
Eligible age
18–60 yrs
Accepts
Men
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
This study aims to study the effects of Oral Progesterone in Transgender Women. The primary goal is to study the effect of progesterone on psychological distress and secondarily on sleep quality, breast size, quality of life and gender congruence and cardiovascular risk.
Sponsor: Emory University
You may qualify if…
- ✓ \- Participants will be transgender women, who have been on gender-affirming hormone therapy for at least 6 months before the start of the study.
You may not qualify if…
- ✕ Peanut allergy
- ✕ Liver disease (liver enzyme elevations and/or evidence of acute or chronic hepatitis). In our lab, the upper limit of normal for aspartate aminotransferase (AST) is 39, and the upper limit of normal for alanine aminotransferase (ALT) is 52.
- ✕ Stage 4/5 chronic kidney disease
- ✕ Congestive heart failure
- ✕ Medical disease or medication use associated with gynecomastia (i.e tumor, hyperthyroidism, chronic kidney disease, cirrhosis, ACE inhibitors, statins, haloperidol, tricyclic antidepressants, atypical antipsychotics)
- ✕ Pre-existing cardiovascular disease
- ✕ Prior or current history of thromboembolism, known clotting disorders, current or recent anti-thrombotic therapy for venous thromboembolism.
- ✕ History of breast cancer
Where it's recruiting
Georgia
Atlanta
Source: ClinicalTrials.gov · NCT06807580 · last updated 2025-12-24