Early Amiodarone in Shockable Cardiac Arrest
Eligible age
18+ yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
The primary objective of this pilot, pragmatic stepped-wedge cluster randomized trial is to evaluate if a modified cardiac arrest treatment algorithm calling for the administration of the initial amiodarone dose one 2-minute cycle earlier than current guidelines (during the same cycle as the initial dose of epinephrine) improves the time to amiodarone delivery in those with out-of-hospital cardiac arrest due to refractory ventricular fibrillation or ventricular tachycardia compared to usual care.
Sponsor: Oregon Health and Science University
You may qualify if…
- ✓ Emergency medical services (EMS)-treated non-traumatic out-of-hospital cardiac arrest
- ✓ Initial rhythm on EMS rhythm assessment of ventricular fibrillation or ventricular tachycardia
- ✓ Recurrence or persistence of ventricular fibrillation or ventricular tachycardia after one defibrillation attempt
You may not qualify if…
- ✕ Known allergy to amiodarone
- ✕ EMS-assessed contraindication to amiodarone
- ✕ Pre-existing "do-not-attempt-resuscitation" orders
- ✕ Inter-facility transportations
- ✕ Initial care by a non-participating EMS agency able to perform advanced life support interventions
- ✕ Pediatric patient as determined by EMS
- ✕ Prisoners
- ✕ Pregnant patients
Where it's recruiting
Portland
Source: ClinicalTrials.gov · NCT06680869 · last updated 2025-12-19