RecruitingEmotional Processing

Losartan and Emotional Processing in Young People

Eligible age

16–20 yrs

Accepts

All genders

Locations

0 states

Healthy volunteers

Yes

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This study explores the effects of single-dose losartan (50mg) versus placebo on emotional processing in young healthy volunteers.

Sponsor: University of Oxford

✓ Willing and able to provide informed consent (for 16 and 17 year olds: assent and parental/ legal guardian consent)
✓ Non- or light-smoker (\< 5 cigarettes a day)
✓ Ability to attend appointments in Oxford with reasonable travel costs
✓ Ability/ willingness to provide GP contact details

✕ Past or present DSM-5 axis-I diagnosis (based on SCID results at screening), especially severe psychiatric illness or alcohol or substance dependence
✕ First-degree family member with severe psychiatric illness
✕ CNS-medication last 6 weeks (including as part of another study)
✕ Current blood pressure or other heart medication (especially aliskiren or beta blockers)
✕ Diagnosis of intravascular fluid depletion or dehydration
✕ Impaired kidney function (based on blood test at screening, cut-off 75 ml/min/1.73 m2)
✕ Significant hyperkalaemia (level\>=6mEq/L in the absence of sample haemolysis will be considered significant hyperkalaemia)
✕ Very low blood pressure (defined as repeated (at least three consecutive measurements) measures of blood pressure under standardised conditions where either the systolic or the diastolic blood pressure or both are below 90/50 mmHg (in accordance with established standard definitions: DOI 10.1186/s12887-016-0633-7))

Source: ClinicalTrials.gov · NCT06636812 · last updated 2025-06-15