Personalized Digital Training Intervention to Reduce Inflammation by Correcting Pathological Movement Patterns in Pre-stage Knee Osteoarthritis After Anterior Cruciate Ligament Reconstruction
Eligible age
18–50 yrs
Accepts
All genders
Locations
0 states
Healthy volunteers
No
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About this study
Osteoarthritis (OA) is a condition that causes pain and stiffness in the joints, often due to injuries like torn ligaments. Even after surgery, these injuries can lead to long-term joint problems. Current treatments don\'t fully prevent OA from developing. This study is testing a new 12-week exercise program designed to improve how the knee moves, using a special sensor-based system. The goal is to reduce joint inflammation and prevent the development of OA in patients who have had knee surgery.
Sponsor: Charite University, Berlin, Germany
You may qualify if…
- ✓ Signed written informed consent
- ✓ Adult subjects between 18 to 50 years old at the time of screening
- ✓ Primary ACL reconstruction within a maximum of 6 months after a unilateral ACL injury
- ✓ Complete baseline assessment between 8 and 12 weeks after ACL reconstruction
You may not qualify if…
- ✕ Significant trauma to a weight-bearing joint within 12 months prior to study initiation (excluding the ACL injury)
- ✕ Previous surgeries on the study knee (except for the ACL reconstruction)
- ✕ Signs of knee OA as defined by the OARSI-Joint Space Narrowing (JSN) Score of two or more (standing AP x-ray)
- ✕ Physical activity level: Tegner activity score before injury of 0-2 (very low activity) or 8-10 (very high activity)
- ✕ Body mass index ≥ 30 kg/m2;
- ✕ Inflammatory arthropathies;
- ✕ Immunosuppression due to illness or medication;
- ✕ Sepsis or hemostasis disorders;
Source: ClinicalTrials.gov · NCT06596824 · last updated 2026-03-02