Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)
Eligible age
18–70 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals. Both groups will have: * screening visit * imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and magnetic resonance spectroscopy \[MRS\] scans) * Overnight visit with intravenous infusion (IV), muscle, and fat tissue biopsies
Sponsor: Bettina Mittendorfer
You may qualify if…
- ✓ age: ≥18 but ≤70 years
- ✓ not pregnant or breastfeeding
- ✓ weight stable and sedentary before enrollment
- ✓ no use tobacco products, excessive amounts of alcohol, or dietary supplements, or medications known to or suspected to affect glucose and lipid metabolism (aside from certain medications used to treat diabetes in the metabolically abnormal obesity \[MAO\]-Type 2 Diabetes group)
- ✓ no evidence of significant organ system dysfunction or disease (e.g. chronic severe kidney disease, cancer)
- ✓ participants must fulfil all of the following group-specific inclusion criteria below:
- ✓ Lean group:
- ✓ Body mass index (BMI) ≥18.5 but \<25.0 kg/m2
You may not qualify if…
- ✕ \- Individuals that do not meet all inclusion Criterion
Where it's recruiting
Columbia
Source: ClinicalTrials.gov · NCT06571474 · last updated 2025-07-22