RecruitingChronic Low-back Pain

Modulation Effect of tACS on Chronic Low Back Pain

Eligible age

18–60 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

See if you qualify for this study

Answer a few quick questions about your location and health. Takes about a minute.

Investigating the modulation effect of tACS

Sponsor: Massachusetts General Hospital

✓ 1. Volunteers 18-60 years of age
✓ 2. Meet the Classification Criteria of the chronic LBP (having low back pain for more than 6 months)
✓ 3. At least 4/10 clinical pain on the 0-10 LBP NRS
✓ 4. At least a 10th grade English-reading level; English can be a second language provided that the patients understand all questions used in the assessment measures
✓ 5. Meeting the MRI / MEG / EEG screening criteria

✕ 1. Specific causes of back pain (eg, cancer, fractures, spinal stenosis, infections)
✕ 2. Complicated back problems (eg, prior back surgery, medicolegal issues)
✕ 3. The intent to undergo surgery during the time of involvement in the study
✕ 4. History of cardiac, respiratory, or nervous system disease that, in the investigator's judgment, precludes participation in the study because of a heightened potential for adverse outcome (for example: asthma or claustrophobia)
✕ 5. Presence of any contraindications to MRI scanning (for example: cardiac pacemaker, metal implants, claustrophobia, pregnancy, cannot lie still in fMRI scanner)
✕ 6. Concomitant autoimmune, chronic, inflammatory, neoplastic, and psychiatric diseases
✕ 7. Pregnant or lactating
✕ 8. Conditions making study participation difficult (e.g., paralysis, psychoses, or other severe psychological problems as per the judgment of a study investigator during Session 1)

Charlestown

Source: ClinicalTrials.gov · NCT06568198 · last updated 2026-03-16