Neurofeedback Enhanced Cognitive Reappraisal Training - Phase 4
Eligible age
18–24 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
Answer a few quick questions about your location and health. Takes about a minute.
About this study
This study seeks to understand emotion regulation in those with young adults with anxiety using real-time functional magnetic resonance imaging neurofeedback, a tool that allows individuals to control brain activity. The goal of this project is to understand how receiving feedback about one's own brain activity relates to emotion regulation ability. This work will help the study team understand the brain areas involved in emotion regulation and could lay the groundwork to test if psychotherapy outcomes can be enhanced using neurofeedback. The study hypotheses include: * Participants receiving veritable-Neurofeedback (NF) will show a greater activation increases in the prefrontal cortex (PFC) compared to sham-NF * Participants receiving veritable-NF will show greater cognitive reappraisal (CR) ability compared to those receiving sham-NF * PFC activation will positively correlate with CR ability
Sponsor: University of Michigan
You may qualify if…
- ✓ Primary diagnosis (primary source of distress and/or interference) of generalized anxiety disorder, social anxiety disorder, panic disorder or illness anxiety disorder based on structured interview. Comorbid phobic disorders allowed, but these cannot be the primary source of interference or distress due to the lowered chances of encountering anxiety-provoking stimuli during the study period
- ✓ Score of 2 or more on at least 1 question from GAD/CROSS-AD composite
- ✓ Medically and physically able to consent
- ✓ Not regularly taking any medication, prescription or non-prescription, with psychotropic effects other than:
- ✓ 1. Buspirone, or antidepressant (e.g., selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI)) with stable dosage for past 4 weeks
- ✓ 2. The same oral hormonal contraceptive for at least 3 months
- ✓ For females, not currently pregnant or actively trying to become pregnant
- ✓ Ability to tolerate small, enclosed spaces without anxiety
You may not qualify if…
- ✕ Current diagnosis of Obsessive Compulsive Disorder, Posttraumatic Stress Disorder, or Bipolar Disorder
- ✕ Current substance abuse or dependence (past 6 months)
- ✕ Active suicidality with plan or intent
- ✕ Current psychosis
- ✕ History of serious neurological illness or current medical condition that could compromise brain function, such as liver failure
- ✕ History of closed head injury, e.g., loss of consciousness greater (\>) approximately (\~) 5 minutes, hospitalization, neurological sequela
Where it's recruiting
Ann Arbor
Source: ClinicalTrials.gov · NCT06563310 · last updated 2026-06-05