Cognition, Flavonoids, Exercise, Gut Microbiome
Eligible age
65–85 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
See if you qualify for this study
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About this study
This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants identified as experiencing age-related cognitive changes. This project's hypothesis is that the combination of flavonoid-rich diet and routine physical activity may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the gut microbiome.
Sponsor: Appalachian State University
You may qualify if…
- ✓ Score on the Montreal Cognitive Assessment (MoCA test) of 24.1-25.2 that indicates mild cognitive decline. The MoCA test score ranges from 0 to 30, with higher scores from 26 to 30 considered normal.
- ✓ Healthy, non-smoking male or female participants 65 to 85 years of age.
- ✓ Capable of engaging in a supervised 12-week exercise training program (brisk walking or stretching).
- ✓ Physically inactive (defined as less than 150 min/week moderate or less than 75 minutes vigorous aerobic and/or resistance exercise during the past 4 weeks).
- ✓ Willingness to be randomized to one of four groups.
- ✓ Willingness to provide blood, urine, and fecal samples (3 each),
- ✓ Willingness to avoid blueberry intake during the 12-weeks study (other than what is provided through the study).
- ✓ Willingness to maintain current diet and physical activity patterns during the study (other than what is prescribed as a part of the study), and make no formal attempts to lose or gain body weight.
You may not qualify if…
- ✕ Allergy to blueberries.
- ✕ Diagnosis of Type I or Type 2 diabetes.
- ✕ Chronic cardiovascular, metabolic, or renal condition that is uncontrolled (controlled defined as stable for 6 months or more).
- ✕ History of signs or symptoms during rest or physical activity such as chest discomfort, unreasonable breathlessness, dizziness, fainting, or blackouts.
- ✕ Use of any prescription or over-the-counter drug intended to support cognition or with known cognitive side effects.
- ✕ Any other concurrent condition or use of medications or supplements which, in the opinion of the study clinician would preclude participation in this study.
- ✕ Diagnosis of dementia.
Where it's recruiting
Kannapolis
Source: ClinicalTrials.gov · NCT06495190 · last updated 2025-03-12