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RecruitingSCI - Spinal Cord Injury

A Novel Repetitive Synchronized Associative Stimulation Neuromodulation Approach for Spinal Cord Injury Patients

Eligible age

18–70 yrs

Accepts

All genders

Locations

1 state

Healthy volunteers

Yes

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About this study

The purpose of this research is to explore the effect of magnetic stimulation to activate the brain, electrical spinal cord stimulation to activate spinal cord, and electrical muscle stimulation used to activate upper limb (arms), lower limb (legs) and trunk (stomach) muscles in people with spinal cord injury (SCI) and able-bodied subjects (without SCI).

Sponsor: University of Miami

You may qualify if…

  • ✓ Male or Female subjects
  • ✓ 1. At least 18 years old and no older than 70 years old at the time of enrollment.
  • ✓ 2. Able-bodied subjects
  • ✓ 3. Traumatic spinal cord injury
  • ✓ 4. Upper limb target: neurological level at or above Thoracic 1 level, Abbreviated Injury Scale (AIS) B, C or D impairment grade, primary non-ambulatory;
  • ✓ Lower limb target: neurological level at or above Thoracic 10 level, with residual lower limb function; AIS B, C or D impairment grade primary could ambulate;
  • ✓ Trunk target: neurological at or above Thoracic 5, AIS A, B, C or D impairment grade, primary wheelchair user
  • ✓ 5. Spinal cord injury sustained more than 6 months prior to study.

You may not qualify if…

  • ✕ 1. Has traumatic brain injury, stroke, multiple sclerosis, or other disorders that could affect neuromotor function.
  • ✕ 2. Has severe spasticity that could prevent the study protocol as determined by the investigator.
  • ✕ 3. Has major executive dysfunction, dementia, depression, neurocognitive impairments, or other major medical co-morbidities.
  • ✕ 4. Has contraindications for transcutaneous stimulation using FES or TSCS such as breakdown of skin in the area that will come into contact with electrodes, thrombosis, or skin disease.
  • ✕ 5. Has a poorly managed autonomic dysreflexia that could be triggered by transcranial magnetic stimulation (TMS), FES, or TSCS.
  • ✕ 6. Has a history of prior intracranial surgery or known medical risks that would limit TMS protocols.
  • ✕ 7. Has a history of epilepsy, convulsion or seizures.
  • ✕ 8. Individuals with metal implants in their head or spine near the sites to be stimulated and other implantable devices (e.g., cochlear implants) in the body that could be affected by TMS or TSCS.

Where it's recruiting

Florida

Miami

Source: ClinicalTrials.gov · NCT06494059 · last updated 2026-04-23

A Novel Repetitive Synchronized Associative Stimulation Neuromodulatio · TrialPath