RecruitingAlzheimers DiseaseMild Cognitive Impairment
Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease
Eligible age
50–90 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
In people with Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), reduced capacity for locomotor adaptation is a fundamental but poorly understood mechanism that can be a sensitive biomarker of cognitive-motor impairments. It is also an important therapeutic target for exercise-based interventions to improve walking function. The overall goal of this study is to understand the effects of MCI and AD on locomotor adaptation and walking function.
Sponsor: Emory University
You may qualify if…
- ✓ AD and MCI will be defined through formal diagnosis provided by a board-certified Neurologist. Amnestic MCI will be defined using the AD Neuroimaging Initiative (ADNI) criteria. All MCI participants in ADNI are required to have an amnestic subtype defined as:
- ✓ Subjective memory concern or a memory problem noted by their partner
- ✓ Abnormal memory function documented by a specified education adjusted cutoff score on the delayed paragraph recall of the Anna Thompson story of the Logical Memory subtest from the Wechsler Memory Scale-Revised
- ✓ Mini-Mental State Exam (MMSE) score between 20 and 26 (inclusive). Exceptions may be made for subjects with less than 8 years of education at the discretion of the PI. (iv) Single or multi-domain amnestic MCI (both subtypes are at high risk for progression to AD)
- ✓ Clinical Dementia Rating (CDR) = 0.5 (Memory Box score must be at least 0.5)
- ✓ General functional performance sufficiently preserved
- ✓ Evidence of impaired executive function based on Montreal Cognitive Assessment (MoCA) score 13-17
- ✓ Able to walk 10 or more feet without an assistive device
You may not qualify if…
- ✕ Acute medical illness requiring hospitalization
- ✕ Uncontrolled congestive heart failure
- ✕ History of stroke
- ✕ Inability to perform study procedures
- ✕ Medical or physical conditions that would preclude participation or walking (e.g., severe arthritis or mobility problems, uncontrolled hypertension or diabetes, renal failure, history of angina with activity)
- ✕ On medications that could adversely affect cognition, eg: antipsychotics, opioids, stimulants, chemotherapy, anti-parkinsonian drugs (eg Levodopa), neurologic prescriptions to treat Multiple sclerosis and/or Parkinson's
- ✕ Psychotic disorders
- ✕ Confounding neurologic conditions (e.g., active central nervous system (CNS) opportunistic infections, seizure disorders, head injury with loss of consciousness \>30 minutes, intracranial neoplasms, stroke with neurological or neuropsychiatric sequelae)
Where it's recruiting
Georgia
Atlanta
Source: ClinicalTrials.gov · NCT06484244 · last updated 2026-03-02