RecruitingObesityHypertension
Cardiovascular Effects of Angiotensin-(1-7) in Obesity Hypertension
Eligible age
18–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
Obesity is a global health concern that is associated with high blood pressure and an increased risk for developing cardiovascular disease. The purpose of this study is to find out if the investigational drug angiotensin-(1-7) can improve cardiovascular health in people with obesity and high blood pressure.
Sponsor: Milton S. Hershey Medical Center
You may qualify if…
- ✓ Men and women of all races
- ✓ Age 18 to 65 years
- ✓ Body mass index (BMI) between 30-45 kg/m2
- ✓ Pre-hypertension (defined as two or more seated blood pressure readings \>120/80 mmHg) or hypertension (defined as two or more seated blood pressure readings \>130/80 mmHg or use of antihypertensive medications)
- ✓ Capable of giving informed consent
- ✓ Fluent in written and spoken English
- ✓ Satisfactory history and physical exam
You may not qualify if…
- ✕ Age ≤ 17 or ≥ 66 years
- ✕ Taking more than two antihypertensive medications
- ✕ Secondary causes of hypertension (e.g., pheochromocytoma, primary aldosteronism, aortic coarctation, adrenal disease)
- ✕ Pregnant or nursing women
- ✕ Women taking hormone replacement therapy within 6 months
- ✕ Decisional impairment
- ✕ Prisoners
- ✕ Alcohol or drug abuse
Where it's recruiting
Pennsylvania
Hershey
Source: ClinicalTrials.gov · NCT06482853 · last updated 2025-09-19