RecruitingObstructive Sleep Apnea
DRonabinol Treatment of OSA
Eligible age
Up to 65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
See if you qualify for this study
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About this study
This is an open-label trial that tests the effectiveness of Dronabinol in treating obstructive sleep apnea (OSA). All participants will take oral Dronabinol for two weeks. Sleep studies will be conducted before and after treatment to measure OSA severity.
Sponsor: VA Office of Research and Development
You may qualify if…
- ✓ 1. Adults 18 to 65 years of age.
- ✓ 2. AHI 15-50 per hour on pre-treatment polysomnography.
You may not qualify if…
- ✕ 1. Positive Airway Pressure (PAP) treatment of OSA: use \> 4 hours per day for 30% of days within 3 months of enrollment. PAP use will be determined from device download data.
- ✕ 2. Hypoglossal nerve stimulator (HNS) or oral appliance device treatment with use \> 4 hours per day for 30% of days within 3 months of enrollment. HNS use will be determined by device download and oral appliance use by self-report.
- ✕ 3. History of upper airway surgery for OSA (except adenotonsillectomy).
- ✕ 4. Central or mixed apneas \>25% of respiratory events on diagnostic polysomnography.
- ✕ 5. Arterial oxygen saturation \< 75% for \> 5% sleep time on pretreatment polysomnography.
- ✕ 6. Body mass index \> 45 kg/m2.
- ✕ 7. If post-bariatric surgery, weight must be stable ±5% (per electronic medical records) for at least 6 months before the first dose of the study drug.
- ✕ 8. Active enrollment in a weight loss program.
Where it's recruiting
Illinois
Chicago
Source: ClinicalTrials.gov · NCT06477952 · last updated 2025-09-12