RecruitingSynucleinopathyParkinson's Disease
Tenapanor in Synucleinopathy-Related Constipation
Eligible age
50–89 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
No
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About this study
Investigation of tenapanor as a potential treatment for synucleinopathy-associated constipation
Sponsor: Cedar Valley Digestive Health Center
You may qualify if…
- ✓ 1. Age 50-89 years.
- ✓ 2. Diagnosis of PD within Hoehn and Yahr stages 1-3, confirmed by a neurologist per International Parkinson and Movement Disorder Society criteria.
- ✓ 3. Average weekly stool frequency of ≤5 spontaneous bowel movements (SBMs) and ≤2 complete spontaneous bowel movements (CSBMs) over the past 6 months. These criteria will be verified during a 2-week screening period.
- ✓ 4. Stool consistency ≤3 on the Bristol Stool Form Scale (BSFS). This criterion will be verified during a 2-week screening period.
- ✓ 5. Agreement to use contraception, if applicable.
You may not qualify if…
- ✕ 1. Functional diarrhea or IBS-D/M based on Rome IV Criteria.
- ✕ 2. Symptomatic structural GI abnormalities or inflammatory bowel disease.
- ✕ 3. Significant hepatic (ALT or AST ≥ 2.5x the upper limit of normal) or renal (serum creatinine \>2mg/dl) dysfunction.
- ✕ 4. Pregnancy or lactation.
- ✕ 5. Diagnosis of primary dyssynergic defecation by anorectal manometry.
Where it's recruiting
Iowa
Waterloo
Source: ClinicalTrials.gov · NCT06460038 · last updated 2025-02-10