RecruitingPreDiabetes
Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes
Eligible age
25–65 yrs
Accepts
All genders
Locations
1 state
Healthy volunteers
Yes
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About this study
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes. However, little is known about the regulation of glucose concentrations in the fasting state relative to what is known about the postprandial state. The proposed experiment is part of a series of experiments designed to establish how glucagon and insulin interact with their receptors to control fasting glucose in health and in prediabetes.
Sponsor: Mayo Clinic
You may qualify if…
- ✓ Individuals with normal or impaired fasting glucose and normal or impaired glucose tolerance
You may not qualify if…
- ✕ HbA1c less than 6.5%
- ✕ Use of any glucose-lowering agents including metformin or sulfonylureas.
- ✕ For female subjects: positive pregnancy test at the time of enrollment or study
- ✕ History of prior upper abdominal surgery such as adjustable gastric banding, pyloroplasty and vagotomy.
- ✕ Active systemic illness or malignancy.
- ✕ Symptomatic macrovascular or microvascular disease.
Where it's recruiting
Minnesota
Rochester
Source: ClinicalTrials.gov · NCT06424106 · last updated 2026-04-20